منابع مشابه
Engineering Cardiac Muscle Tissue
The origin of the term tissue engineering is not clear, but a 1985 proposal of Y.C. Fung to the National Science Foundation of the United States for a Center for the Engineering of Living Tissues and 2 conferences organized by the National Science Foundation in 1987 and 1988 are generally accepted as the origin of this lively and rapidly growing research field (The Emergence of Tissue Engineeri...
متن کاملManufacturing a Biomimetic Biorecator in Cardiac Tissue Engineering
Introduction: The direct approach of cardiac tissue engineering is to mimic the natural tissue of heart, considering the significant role of scaffolding and mechanical simulation. Methods: To achieve this purpose, a composite Polycaprolactone (PCL)/Gelatin electrospun scaffold with a ratio of 70:30 and with the most similarities to the cardiac extracellular matrix was fabricated with aligned ...
متن کاملApplications of Small Molecules in Muscle Tissue Engineering
Introduction: Skeletal muscles account for about 40% of the total body weight. Every year, hundreds of people lose at least part of their muscle tissue due to illness, war, and accidents. This can lead to disruption of activities such as breathing, movement, and social life. To this end, various therapeutic strategies such as medication therapy, cell therapy and tissue transplantation have been...
متن کاملTissue engineering of a differentiated cardiac muscle construct.
Cardiac tissue engineering is an emerging field. The suitability of engineered heart tissue (EHT) for both in vitro and in vivo applications will depend on the degree of syncytoid tissue formation and cardiac myocyte differentiation in vitro, contractile function, and electrophysiological properties. Here, we demonstrate that cardiac myocytes from neonatal rats, when mixed with collagen I and m...
متن کاملEngineering Virtual Cardiac Tissue
The kinetics of proteins involved in ion transfer, sequestration and binding in cardiac cells can be modelled to construct a model of the electrical activity of isolated cardiac cells as a system of ordinary differential equations. These cell models may be incorporated into tissue models, which, when combined with histology and anatomy, form virtual tissues. The effects of changes in specific p...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2017
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.117.310738